History of Centrophenoxine

Centrophenoxine, which is also known as “Meclofenoxate” and popularly marketed as “Lucidril” is a potent cholinergic nootropic that can be taken to improve overall brain performance and treat various cognitive disorders among other essential benefits. This amazing nootropic is synthesized from “Dimethylaminoethanol (DMAE),” which is also a well-respected nootropic supplement.

Despite being derived from DMAE and having almost the same benefits as the nootropic, Centrophenoxine has been specially modified to increase its potency, enhance its unique ability to cross the blood-brain barrier (making it more fat-soluble) and to improve its absorption. The relatively affordable nootropic supplement has a long track record of success and is backed by over 50 years of scientific research and testing.

Meclofenoxate was first developed in the year 1959 by various scientists who were working at the “French National Scientific Research Center.” Though now commonly used almost entirely for its cognitive enhancement and nootropic properties, this nootropic was originally created as a potent treatment option for Alzheimer’s disease and other cognitive disorders.

Centrophenoxine, although generally considered to be an effective dietary supplement, is currently being sold as a prescription drug in various countries like Japan, Austria, Germany, and Hungary. Being a potent cholinergic compound (a substance with the ability to increase acetylcholine levels), Meclofenoxate is often used in many nootropic stacks to increase their potency.

The overall user profile for this nootropic supplement that has been scientifically proven to significantly boost concentration, learning ability, fluid intelligence, and long-term memory is quite safe. This alone makes the supplement very easy to take and recommend to other nootropic users.

How Centrophenoxine Works

Just like all other popular Nootropics, the exact mechanism of action of this supplement has not been clearly understood. It is, however, generally agreed that the super-effective supplement works to increase acetylcholine levels in the synaptic vesicles after crossing the blood-brain barrier. Acetylcholine is an essential brain neurotransmitter that is typically strongly associated with general cognitive acuity, increased brain plasticity, and memory.

It is also claimed that Centrophenoxine can stimulate overall brain activity. Doing this then translates into improved glucose absorption and increased oxygen uptake to energize the brain, thus; making it work optimally. This, in turn, results in improved clarity of thought, concentration, and focus.


Common Centrophenoxine Benefits

Improved brain function

The nootropic is a potent neuro energizer that can effectively stimulate oxygen consumption and glucose uptake. By doing so, the chemical compound makes learning a lot easier while also increasing all major brain functions.

Enhanced fluid intelligence

This nootropic compound has the ability to enhance fluid intelligence, which is the unique ability to solve various problems without having to rely on the acquired knowledge.

Addressing common cognitive issues

Lucidril is used together with popular Alzheimer’s prescription drugs to increase their effectiveness. The nootropic compound has also been scientifically proven to be a potent antidepressant and mild depressant, hence; can help with ADHD, stress, and other mood issues.

Improved memory

As previously indicated, this potent nootropic facilitates the increased production of acetylcholine. Increasing this essential brain neurotransmitter results in improved memory and other cognitive functions.

Halting or even reversing the effects of brain aging

Meclofenoxate is a potent antioxidant, neuroprotectant and free radical scavenger that can repair damaged brain cells, flush out toxins found in the brain and protect the brain from brain aging (age-related deterioration).

Multiple scientific studies indicate that this nootropic supplement can easily help to improve common brain aging symptoms, including memory loss, concentration, and age-related confusion.

Potential Side Effects and Safety Concerns 

Centrophenoxine is generally considered to be a safe and a well-tolerated nootropic supplement. However, some rare and mild side effects, including insomnia, headache, depression, muscle tension, nausea, dizziness, muscle tremor and restlessness may occur when the supplement is overused.

Pregnant women should refrain from using this nootropic supplement as it is known to cause various birth defects. People under medication should always consult their health practitioners before using this nootropic supplement.

Recommended Dosage

The generally recommended Meclofenoxate dosage is between 300 and 1000 milligrams per day. However, this can greatly vary depending on the user’s goals, personal preferences, and sensitivity levels. Starting with the lowest possible dose and later increasing gradually is the most recommended course of action.

This nootropic supplement should only be taken with food due to its fat-soluble nature. Apart from this, the essential compound should always be stored in the refrigerator to prevent it from degrading.


Centrophenoxine is a leading nootropic supplement that can be taken to boost long-term memory, among other things. There is sufficient evidence that proves that this nootropic can be taken to slow multiple aging symptoms and help keep the brain healthy.

Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.