A Guide to Nootropic Mood Enhancers

While life in this 21st century is the most advanced and easiest time period to date, it can sometimes feel as if things are moving too fast.  Stress levels get high and people lose sight of how great life really is. Sometimes people just need a small boost to help them realize the good again.  This is where mood enhancers can help.

Researchers have developed various mood enhancing supplements and drugs that can help restore your balance, uplift your spirit and promote feelings of well-being. Most of these drugs and supplements work by modulating serotonin and dopamine neurotransmitters within the brain in order to restore the biochemical balance.

Some of the most well-known mood enhancers are nootropic supplements.  Nootropics are supplements designed to improve cognitive performance in areas such as memory, creativity, executive functions, and motivation.

Most people use nootropics to benefit from their ability to enhance cognitive function and improve focus. However, there are people who use nootropics primarily to enhance their mood. Nootropics have been used for ages to treat anxiety, depression, ADHD, and many other mood-related disorders.

It is, however, important to mention that nootropics cannot be relied on independently in curing acute cases of mood disorders. If you have chronic anxiety or depression, for instance, nootropics cannot offer an instant cure, however, they can be used to suppress the symptoms as you seek professional help.

With that in mind, nootropics can greatly help you control your mood and regulate your emotions with very minimal to no side effects. One of the main advantages of using mood enhancers compared to dieting and exercise is that they are easy to incorporate in your everyday routine without having to change your lifestyle.

How Do Nootropics Enhance Mood?

As earlier mentioned, nootropics enhance mood by working with the brain’s natural chemistry. They do so by directly impacting on a number of neurotransmitters in our brains. Neurotransmitters like serotonin, acetylcholine, and dopamine tell our brain to feel happy, feel motivated, feel anxious and many other mood-related expressions.

More specifically, nootropics work by increasing the natural production of neurotransmitters and increasing the ability of receptors to receive these Neurotransmitters. These two major modes of action work together to enhance our mood and deliver many other health benefits.

Common Mood Enhancers That Work

There are dozens of mood enhancers that claim to have some effect on our cognitive function and mood stabilization. However, not all of them offer the same effects and experience. We have selected the best 4 that offer the best beneficial effects in reducing anxiety, stress, and depression to better our mood.

Sulbutiamine ~ a thiamine derivative with some unique properties that make it one of the best mood enhancers in the market. It works by stimulating the levels of dopamine in the brain to offer some powerful benefits including depression reduction, stress reduction, increased energy and heightened mental alertness.

One of the main reasons why Sulbutiamine is so effective is its high bioavailability. This means it can easily be absorbed into the bloodstream and quickly cross the blood-brain barrier to instantly exert its effects to the central nervous system. The general recommended dosage rate for Sulbutiamine is between 400mg and 1000mg per day. This should be taken in 2-3 splits spread throughout the day for prolonged effects.

Phenibut ~ a natural derivative of a neurotransmitter known as GABA (gamma-aminobutyric acid). It regulates the “neuronal excitability” that occurs in the central nervous system to prevent the brain from becoming hyperactive. Phenibut works as a mood enhancer by stimulating dopamine receptors to create a feeling of well-being.

In addition to mood enhancement, Phenibut benefits users by lessening anxiety and stress, enhancing focus, relaxing muscles, and providing a general sedative effect. The general recommended dosage range for use as a mood enhancer is between 200mg and 500mg per day taken in 2-3 equal splits.

Picamilon ~ a nootropic supplement that combines GABA and Niacin (Vitamin B3) to offer profound benefits to both the mind and body. Specific benefits that most Picamilon users have reported include reduced stress and anxiety, improved memory, increased learning speed, better sleep and mood stabilization.

Recommended dosage ranges from 50mg to 400mg per day taken in 2-3 equal splits. As you can see, the dosage range is quite wide too, which means it’s very well tolerated and safe. However, if you intend to use Picamilon primarily for mood stabilization, consider using lower dosages of 200mg per day and below.

Tianeptine ~ a drug primarily designed for use in the treatment of depression disorders. It has antidepressant and antianxiety properties with a variety of effects such as anxiety suppression, motivational enhancement, cognitive euphoria, rejuvenation and most importantly, mood stabilization. When it comes to Tianeptine dosage, you want be very careful because it’s extremely potent compared to other nootropics. The general recommended dosage range is between 12.5mg and 25mg per day taken in 2-3 splits.


Mood enhancers can be effective in helping you handle stress, anxiety, and depression to help you stay motivated at all times. The best part about using nootropics is that they are completely safe with no toxicity to humans. Additionally, they are easy to incorporate into your everyday routine without changing your lifestyle. The same can’t be said about diet and exercise; which are the recommended options for mood stabilization.

Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.