What is Picamilon?

Picamilon is a nootropic compound created by synthetically combining niacin and gamma-Aminobutyric acid or GABA, two essential nutrients with an important role to play in maintaining a healthy brain. This compound is considered unique because it not only has nootropic effects, like improving brain function, memory, attention span, motivation, and concentration, it also seems to help in reducing stress and anxiety as it has calming and relaxing effects.

This compound is used by people who are looking to improve their cognitive function and energy levels but also require assistance in alleviating stress and anxiety symptoms. It is also used to treat various medical issues, including neuro-infections, some forms of glaucoma, migraines, acute alcohol intoxications, and senile psychosis.

Picamilon was developed in Russia, at the All-Union Vitamin Research Institute sometime in the late 1960s to the early 1970s, though no one is certain of the precise date. It was part of a program where the Institute was researching and attempting to develop drugs designed to enhance performance.

While the compound is currently sold in Russia as a prescription drug to treat a variety of neurological conditions, including glaucoma, neuro-infections, migraines, senile psychosis and more, in the United States, it is not approved as a drug or as a dietary ingredient. In other words, in the US, Picamilon cannot be sold either as a supplement or a drug.

How Does Picamilon Work?

Picamilon is a compound in which niacin and GABA have been combined. The advantage of this compound is that niacin can cross the blood-brain barrier, which protects the brain. When it does so, it carries the GABA component across with it. Normally, GABA cannot cross this barrier on its own, which is why the compound is so effective and considered better than taking the two elements separately.

GABA is responsible for the reduction of neuronal excitability through its slight sedative effect, meaning that it’s the component which lowers stress and anxiety levels. The niacin helps to improve blood flow as well as oxygen and other nutrient absorption rates, essentially making the brain more efficient.

Improved blood flow also means glucose and various other nutrients are delivered and absorbed more efficiently, leading to a boost in focus, alertness, and motivation. In other words, it improves the overall energy of the brain.

It is also believed that this compound helps to disintegrate and eliminate toxins in the brain through its antioxidant effect.

Benefits of Using Picamilon

Picamilon offers a wide range of benefits in terms of improved brainpower but also for mood management. Thus, one area where this compound has been shown to shine is learning and memory improvement by increasing the speed at which patients are able to learn thanks to increased recall speed and better memory retention.

It also seems to have quite a positive effect on a number of brain functions thanks to the improved blood circulation it promotes throughout the brain. The results are an increased capacity to focus and better mental stamina and energy.

Patients taking this compound have also found that their anxiety and stress symptoms are greatly reduced thanks to the increased levels of GABA. There is a belief that it could also help in treating depression. It has also been reported that patients feel pleasantly relaxed when taking this compound, making it a good alternative to a mild sedative, especially since it doesn’t cause the grogginess or mental fog associated with such sedatives.

In some cases, this compound has been shown to reduce blood pressure, which makes it of benefit to anyone suffering from hypertension whose condition is aggravated by anxiety and stress.

Picamilon Side Effects

Generally, Picamilon is considered safe and most patients tolerate it well. However, there have been a few cases where side effects have occurred. Thus, in some cases, it can cause low blood pressure, which means that if you suffer from hypotension or are worried for any reason about having low blood pressure, you should consult your doctor before taking this supplement.

The most common side effects tend to be dizziness, headaches, nausea, and lightheadedness, along with skin rashes and allergic reactions but more rarely. A common and practically harmless side effect caused by niacin is a red flush in the skin, but the occurrence isn’t too frequent.

Picamilon Dosage

Picamilon is a highly potent supplement and care should be employed when taking it. Ideally, you should start taking the lowest possible dosage of this compound that is still effective. It should be noted that recommendations vary significantly and the amount you take depends mainly on what you are hoping to achieve.

Thus, the most cumulative dosages range between 50 mg and 400 mg per day. In most cases, between 100 mg and 200 mg twice or three times daily is enough for most people. If you’re looking to use this compound as a mood stabilizer and to improve cognitive function, then lower dosages will be sufficient. If you want to see substantial improvements in your energy, then you will likely have to increase the dosages gradually.


Picamilon is a powerful nootropic due to its wide range of benefits. Few supplements have the ability to both improve mental energy and function while also reducing stress and anxiety symptoms, which is this compound is so powerful, especially considering the few and relatively rare side effects. Picamilon is ideal for anyone who wants to maximize brainpower, increase energy levels and function well in stressful and anxiety inducing situations.

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Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.