Adrafinil vs Modafinil

Modafinil and Adrafinil are used to treat narcolepsy, obstructive sleep apnea, and idiopathic hypersomnia. They are also widely used off-label to enhance cognitive performance, improve memory, focus. and general alertness.  When comparing Adrafinil vs Modafinil it is important to understand their similarities and their differences.

The two are classified as psychostimulants and are consumed orally. They have a nearly similar chemical structure only that Adrafinil is a precursor drug to modafinil. Which means when you consume Adrafinil, it’s first synthesized by the liver to produce modafinil, so eventually; both drugs produce the same active metabolite known as modafinilic acid.

So, which is the best between Adrafinil and Modafinil? Honestly speaking, the two drugs produce very similar effects, but experiences may vary from one user to another. So what might be best for you between these two might not necessarily meet the expectations of another user. It might be helpful to take a closer look at the key differences in terms of benefits and side effects to determine what is really best for you.

Adrafinil vs Modafinil Benefits

Adrafinil was originally designed to help people with sleep problems such as sleep apnea and narcolepsy. One of the most notable benefits is promoting alertness and wakefulness, which helps people normalize their sleep patterns.

Most Adrafinil users have also reported experiencing higher energy levels after using this supplement. This is because Adrafinil increases the levels of Hypocretin –a neurotransmitter that controls how awake and alert a person feels.

Adrafinil also leads to increased levels of catecholamines, which contributes to higher energy levels in the brain, awareness, focus, attention span, and physical stamina. Other neurotransmitters also elevated within the brain include dopamine and serotonin. The two form part of the brain’s reward system which promotes feelings of pleasure and satisfactions while reducing stress, anxiety, and fatigue.

Adrafinil users report a general feeling of motivation, better mood, enhanced cognitive performance, and improved memory.

Modafinil works in a somewhat similar manner to Adrafinil, although some reviews report that Modafinil is fast acting and its effects last for longer. The drug is designed to promote alertness and wakefulness which is key in treating sleep disorders and excessive daytime fatigue.

Modafinil also acts on the central nervous system to increase both mental and physical energy levels. Its cognitive effects are similar to those of Adrafinil, which include improved memory, speed of thought, learning capacity, and attention span.

Adrafinil vs Modafinil Dosage

The standard recommended dosage for modafinil is 200mg per day; however, some users have reported intensive effects at higher doses of up to 400mg per day. The general recommended dosage range is between 100mg and 400mg per day.

On the other hand, Adrafinil is considered less potent compared to modafinil, for this reason, you will require more of it to achieve the same results. The general recommended dosage for Adrafinil is between 600mg and 1,200mg per day.

Adrafinil vs Modafinil Side Effects

Both drugs may elicit feelings of anxiety, irritability, nausea, and gastrointestinal distress. The two also tends to suppress appetite, which may be a plus or a negative, depending on who you ask. Adrafinil, in particular, has raised a few issues regarding its effect to the liver. This is because it has to be first synthesized by the liver into Modafinil for it to kick into action.


Both drugs have similar effects when it comes to promoting wakefulness, but their overall effects may vary from one person to another depending on their age, tolerance, health and so on. So the best way to determine what is really right for your body is by trial and error.  When it comes down to Adrafinil vs Modafinil, it is a matter of personal taste.  Most reviews claim that Modafinil is usually the favorite by serious users but Adrafinil is often used to avoid the legal issues surrounding Modafinil.

Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.