Armodafinil vs Modafinil

Armodafinil and Modafinil are both non-amphetamine drugs used to promote wakefulness and in the treatment of sleep disorders such as narcolepsy, chronic sleep apnea, and excessive sleepiness. They are also both approved by FDA for the above-named uses. Both drugs have increasingly been used off-label for combating anxiety, increasing calmness and enhancing mood.

Both drugs were developed by a France pharmaceutical company called Cephalon, with Modafinil hitting the market early in 1998 and Armodafinil coming in later as a follow-up in 2007. Armodafinil is actually a modified form of Modafinil with a little difference in the chemical structure.

Even though these two drugs seem to do give the same effects and have a common origin, there are a few differences that make each supplement slightly unique in how they work. This Armodafinil vs Modafinil article will take a look at the similarities and differences between the two in various aspects and why you may choose one over the other.

Chemical Differences

The most significant chemical difference between armodafinil vs modafinil is that Modafinil contains both the R and S enantiomers of the modafinil molecule, while Armodafinil contains only the R-enantiomer. As a result of Armodafinil having the R enantiomer alone, its effects last two more hours compared to modafinil.

In more simple terms, you can think of Armodafinil as an updated and more purified form of modafinil. This is why the standard dosage for modafinil is 200mg per day whereas that of Armodafinil is only 150mg.

Armodafinil vs Modafinil Benefits

Modafinil was actually the first drug to offer real relief to patients suffering from obstructive sleep apnea, narcolepsy, and other serious sleep issues. The supplement acts as a wakefulness agent that helps to normalize sleep patterns and help users get rid of mental fatigue.

Modafinil is widely used to promote feelings of wakefulness and mental energy. Many users have reported feeling fully focused, alert and more productive after using this supplement. Increased focus also improves memory formation and retrieval as well as the speed of thought. Though uncommon, a few users have taken Modafinil to support weight loss due to the fact that it suppresses appetite.

The effects and benefits of Armodafinil are quite similar to those of Modafinil. It also promotes wakefulness and focus, but with no risk of developing dependence or addiction as opposed to modafinil.

While Modafinil may disturb your sleep patterns when taken twice per day, Armodafinil drops off its effects quite suddenly and you will be able to go to sleep at your normal sleeping hours. Some users have reported being unable to go to sleep within 5-10 hours of taking Modafinil, which is not the case with Armodafinil.


There are various other subjective differences of Armodafinil vs Modafinil depending on how the drug affects an individual. But the main difference seems to be that Armodafinil effects last longer compared to Modafinil. There is a general impression that Armodafinil is more potent and effective than Modafinil, however, both drugs have received numerous positive reviews and are doing quite fine in the market. To determine the real difference between the two, you might want to try them out and assess the experiences in person.

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Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.