Tianeptine Dosage Recommendation

Tianeptine is primarily an antidepressant used to treat depression, anxiety disorders, bipolar disorder and acute stress. It works by modulating actions of a neurotransmitter in the brain known as glutamate. Tianeptine could be considered one of the most powerful nootropics on the market today, especially once the tianeptine dosage is dialed in properly.

The drug is classified as a selective Serotonin reuptake enhancer (SSRE), hence its ability to modulate feelings of stress.  Stress and depression are directly linked to neuroplasticity –the brain’s ability to adapt to new stimuli. The more neuroplasticity a person has means their brain retains more control and reduces symptoms of depression.

Tianeptine Sodium Vs Tianeptine Sulfate

Like many other drugs, Tianeptine is formulated into various salt forms to offer maximum absorption, bioavailability, and overall effectiveness. Tianeptine is most commonly found in sodium form because this is the only version prescribed by doctors. However, sulfate forms are also coming up and are in fact thought to be superior in efficacy, and their effects last longer than those of the sodium version.

Generally, Tianeptine sulfate is metabolized slower by the body, making a single dose per day effective. Researchers have indicated that since the sulfate version is metabolized slower, there is less chance of addiction. There is however not much published about the sulfate version as most of the research work is still ongoing.

Unlike most nootropic supplements, Tianeptine offers a narrower dosage range of 12.5mg to 25mg per day. The pills typically come in 12.5mg formulations, as for the powder; you are at liberty to experiment with measurements within the recommended range.

Among many other factors, your Tianeptine dosage will be influenced by its formulation. The dosage recommendation for Tianeptine sodium is 12.5mg per day taken in three splits. Tianeptine sulfate is often taken at a dosage rate of 25mg per day taken in 1-2 splits. Splitting the doses up in both cases generally, help to offer consistent effects of the drug throughout the day.

New users are advised to begin with a lower Tianeptine Dosage –so you may want to cut the tablet in half, take one-half in the morning and the second half at night. If you have to increase the dosage, only do so once you are familiar with the drug’s effects.

Tolerance and Addiction Potential

Chronic use of Tianeptine has been reported to cause mild addiction with a potential of causing both psychological and physical dependence. Some individuals may show withdrawal symptoms if they suddenly stop the use of this drug in the event of a physical dependence.

Tolerance to most of the Tianeptine effects can develop in cases of prolonged use. Tolerant users will often need to take increasingly large doses to achieve the same results. It can take up to 2 weeks to completely reverse the tolerance back to baseline.


Tianeptine is highly potent and its dosage should be observed carefully to avoid potential side effects. If Tianeptine dosage recommendations are keenly followed, users can enjoy beneficial effects such as reduced stress, anxiety, and depression without any negative side effects. It is also important to mention that Tianeptine is a prescription drug, so unless you are very experienced with nootropic supplements, be sure to consult your doctor before using it.

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Nicole Sanders

Hi, I'm Nicole, chief editor at Nootropics Revealed. Learn more about me and my mission here.